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1024 matches
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organism
protein
1)
Homo sapiens
RPA1 - Replication
protein
A 70 kDa
DNA
-
binding
subunit, N-terminally processed; As part of the heterotrimeric replication
protein
A complex (RPA/RP-A),
binds
and stabilizes single-stranded
DNA
intermediates, that form during
DNA
replication or upon
DNA
stress
. It prevents their reannealing and in parallel, recruits and activates different
proteins
and complexes involved in
DNA
metabolism. Thereby, it plays an essential role both in
DNA
replication and the cellular response to
DNA
damage. In the cellular response to
DNA
damage, the RPA complex controls
DNA
repair and
DNA
damage checkpoint act [...]
[a.k.a. ENSG00000132383, R-HSA-5696395, R-HSA-69278]
2)
Homo sapiens
CREB3L1 - Processed cyclic AMP-responsive element-
binding
protein
3-like
protein
1; Transcription factor involved in unfolded
protein
response (UPR).
Binds
the
DNA
consensus sequence 5'-GTGXGCXGC-3'. In the absence of endoplasmic reticulum (ER)
stress
, inserted into ER membranes, with N-terminal
DNA
-
binding
and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER
stress
, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated [...]
[a.k.a. AAH15781.1, ENSP00000431677, AB063321]
3)
Homo sapiens
HSF1 - Heat shock factor
protein
1; Functions as a
stress
-inducible and
DNA
-
binding
transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock
proteins
(HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-
DNA
-
binding
inactivated monomeric form. Upon exposure to heat and other
stress
stimuli, undergoes homotrimerization and activates HSP gene transcription [...]
[a.k.a. E9PMQ6, UPI0000000DE5, E9PI02]
4)
Homo sapiens
HABP4 - Intracellular hyaluronan-
binding
protein
4; RNA-
binding
protein
that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates
DNA
-
binding
activity of the transcription factor MEF2C in myocardial cells in response to mechanical
stress
(By similarity). Plays a role in pre-mRNA splicing regulation.
Binds
(via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation.
[a.k.a. hyaluronan binding protein 4, ENSP00000364398, Hyaluronan binding protein 4]
5)
Homo sapiens
CREB3L2 - Processed cyclic AMP-responsive element-
binding
protein
3-like
protein
2; Transcription factor involved in unfolded
protein
response (UPR). In the absence of endoplasmic reticulum (ER)
stress
, inserted into ER membranes, with N-terminal
DNA
-
binding
and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER
stress
, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...]
[a.k.a. CREB3L2-206, NM_001253775.2, ENSP00000329140]
6)
Homo sapiens
HSBP1 - Heat shock factor-
binding
protein
1; Negative regulator of the heat shock response. Negatively affects HSF1
DNA
-
binding
activity. May have a role in the suppression of the activation of the
stress
response during the aging process; Belongs to the HSBP1 family.
[a.k.a. Q53XA8, heat shock factor binding protein 1, HSBP1-202]
7)
Mus musculus
Rpa1 - Replication
protein
A 70 kDa
DNA
-
binding
subunit; As part of the heterotrimeric replication
protein
A complex (RPA/RP-A),
binds
and stabilizes single-stranded
DNA
intermediates, that form during
DNA
replication or upon
DNA
stress
. It prevents their reannealing and in parallel, recruits and activates different
proteins
and complexes involved in
DNA
metabolism. Thereby, it plays an essential role both in
DNA
replication and the cellular response to
DNA
damage. In the cellular response to
DNA
damage, the RPA complex controls
DNA
repair and
DNA
damage checkpoint activation. Through recruit [...]
[a.k.a. R-MMU-453279, R-MMU-5696398, MGI:1915525]
8)
Mus musculus
Hsf3 - Heat shock factor
protein
3;
DNA
-
binding
protein
that specifically
binds
heat shock promoter elements (HSE) and activates transcription of non-classical heat-shock genes such as PDZD2 and PROM2. Protects cells against heat shock and proteotoxic
stress
; Belongs to the HSF family.
[a.k.a. NP_001297684, UPI00000276F6, UPI0001F796FA]
9)
Mus musculus
Hsf1 - Heat shock factor
protein
1; Functions as a
stress
-inducible and
DNA
-
binding
transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones heat shock
proteins
(HSPs) that protect cells from cellular insults' damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-
DNA
-
binding
inactivated monomeric form. Upon exposure to heat and other
stress
stimuli, undergoes homotrimerization and activates HSP gene transcriptio [...]
[a.k.a. Hsf1-215, XP_006520536.1, mmu:15499]
10)
Mus musculus
Creb3l1 - Processed cyclic AMP-responsive element-
binding
protein
3-like
protein
1; Transcription factor involved in unfolded
protein
response (UPR).
Binds
the
DNA
consensus sequence 5'-GTGXGCXGC-3' (By similarity). In the absence of endoplasmic reticulum (ER)
stress
, inserted into ER membranes, with N-terminal
DNA
-
binding
and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER
stress
, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain [...]
[a.k.a. ENSMUSP00000028663, ENSMUST00000028663, ENSMUST00000099708]
11)
Mus musculus
Habp4 - Intracellular hyaluronan-
binding
protein
4; RNA-
binding
protein
that plays a role in the regulation of transcription, pre-mRNA splicing and mRNA translation. Negatively regulates
DNA
-
binding
activity of the transcription factor MEF2C in myocardial cells in response to mechanical
stress
. Plays a role in pre- mRNA splicing regulation.
Binds
(via C-terminus) to poly(U) RNA. Involved in mRNA translation regulation, probably at the initiation step. Seems to play a role in PML-nuclear bodies formation (By similarity).
[a.k.a. 4933413D03Rik, Hyaluronic acid binding protein 4, mmu:56541]
12)
Mus musculus
Creb3l2 - Processed cyclic AMP-responsive element-
binding
protein
3-like
protein
2; Transcription factor involved in unfolded
protein
response (UPR). In the absence of endoplasmic reticulum (ER)
stress
, inserted into ER membranes, with N-terminal
DNA
-
binding
and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER
stress
, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific [...]
[a.k.a. cAMP responsive element binding protein 3-like 2, XP_006505887.1, AK041050]
13)
Mus musculus
Hsbp1 - Heat shock factor-
binding
protein
1; Negative regulator of the heat shock response. Negatively affects HSF1
DNA
-
binding
activity. May have a role in the suppression of the activation of the
stress
response during the aging process (By similarity).
[a.k.a. ENSMUSP00000034300, NM_024219, BAE26770.1]
14)
Drosophila melanogaster
RpA-70 - Replication
protein
A 70 kDa
DNA
-
binding
subunit; As part of the heterotrimeric replication
protein
A complex (RPA/RP-A),
binds
and stabilizes single-stranded
DNA
intermediates, that form during
DNA
replication or upon
DNA
stress
. It prevents their reannealing and in parallel, recruits and activates different
proteins
and complexes involved in
DNA
metabolism. Thereby, it plays an essential role both in
DNA
replication and the cellular response to
DNA
damage.
[a.k.a. FBgn0010173, RpA-70-PA, 40972]
15)
Drosophila melanogaster
S2P - Metalloendopeptidase activity. It is involved in the biological process described with: positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum
stress
; sterol regulatory element
binding
protein
cleavage; membrane
protein
intracellular domain proteolysis; positive regulation of
DNA
-
binding
transcription factor activity.
[a.k.a. FBgn0033656, S2P-PA, AY071529]
16)
Drosophila melanogaster
Ets21C -
DNA
-
binding
protein
D-ETS-6; Ets at 21C (Ets21C) encodes a
stress
-inducible transcription factor that
binds
specifically to purine-rich
DNA
motifs. It cooperates with transcription factors acting downstream of the MAP kinase pathways to fine tune gene expression in response to
stress
, such as infection or oncogene activation.
[a.k.a. FBgn0005660, Ets21C-PA, Ets21C-PB]
17)
Caenorhabditis elegans
tdp-1 - Tar
DNA
-
binding
protein
homolog 1; RNA-
binding
protein
which regulates transcription, splicing and RNA-editing. Limits the accumulation of double- stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs.
Stress
response
protein
that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular
stress
response to osmotic, oxidative, proteotoxic and endoplasmic reticulum
stress
. Involved in the regulation of physiological processes including aging, fertility, growth and locomotion.
[a.k.a. F44G4.4c, NP_001022166, NP_001022166.1]
18)
Saccharomyces cerevisiae
CMR1 -
DNA
damage-
binding
protein
CMR1; Nuclear
protein
with a role in
protein
quality control; localizes to the intranuclear quality control compartment (INQ) in response to proteasome inhibition or
DNA
replication
stress
; INQ likely sequesters
proteins
involved in
DNA
metabolism for degradation or re-folding;
DNA
-
binding
protein
with preference for UV-damaged
DNA
; contains three WD domains (WD-40 repeat); human ortholog WDR76 also exhibits perinuclear localization under similar
stress
conditions.
[a.k.a. YDL156W, 4932.YDL156W, NM_001180216.1]
19)
Saccharomyces cerevisiae
MBF1 - Multiprotein-bridging factor 1; Transcriptional coactivator; bridges the
DNA
-
binding
region of Gcn4p and TATA-
binding
protein
Spt15p; suppressor of frameshift mutations;
protein
abundance increases in response to
DNA
replication
stress
; Belongs to the MBF1 family.
[a.k.a. YOR298C-A, CAA99530.1, NM_001184346.3]
20)
Escherichia coli K12
cbpA - DnaK co-chaperone;
DNA
-
binding
protein
that preferentially recognizes a curved
DNA
sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental
stresses
other than heat shock. Lacks autonomous chaperone activity;
binds
native substrates and targets them for recognition by DnaK. Its activity is inhibited by the
binding
of CbpM.
[a.k.a. b1000, AAC74085.1, eco:b1000]
1024 matches
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